Kate and Humphrey, two of Raccoon City's best S.T.A.R.S. agents are sent to investigate the mysterious disappearances of former member Albert Wesker. Accompanied bởi Garth and Lilly, two rookies, they encounter the HIVE, Umbrella's hàng đầu, đầu trang secret bio-weapon lab. But while the investigation continues, a deadly bio-weapon virus escapes and causes infection throughout the city. Will they get out alive? hoặc will they be infected.