Yuki Cross's earliest memory is of being attacked bởi a vampire and saved bởi Kaname Kuran, also a vampire. Ten years later, Yuki and a vampire hunter, Zero Kiryu attend vượt qua, cross Academy as school guardians protecting the "Day Class" and the "Night Class" from each other to keep ma cà rồng secret. The story follows Yuki's discovery that her childhood friend, Zero, has spent the last four years trying to fight his transformation into a vampire, and he has finally succumbed. Yuki struggles to help Zero fight his bloodlust and to recover her own Mất tích memories, while suspecting that Kaname knows thêm than he is saying.

When his uncle, Rido Kuran, returns to kill Yuki, Kaname is forced to reveal her secret bởi biting Yuki and awakening her true nature as a vampire, returning her memories of being Yuki Kuran, his younger sister. Rido is killed bởi Zero and Yuki while Kaname faces and destroys Rido's allies, the Vampire Council, revealing himself to be one of the original ma cà rồng and the founder of the Kuran clan. Yuki and Zero part as enemies after Zero reveals he intends to end everything, bởi killing all purebloods, even her. Yuki leaves with Kaname and they return to the Kuran family home. The story restarts a năm later with Yuki's dealing with vampire society and new enemies, such as Sara Shirabuki.