anime big sisters who had little brothers

sango and kohaku
inuyasha

Ukraine and Russia from Hetalia

May has a little brother-his name is Max

Mirai Kamiki from Gundam Build Fighters Try for Sekai of that show.
I'm only going to bother with this vid, try not to be sore about it(No pun intended).

no pic but tokyo magnitude 8.0 there is a big sister and her little brother trying to make it home

Tsunade & Nawaki (Naruto Shippuden)